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NICE April 2004 ; , has recommended that `because of the lack of compelling evidence to distinguish between these drugs, or the shorter-acting benzodiazepine hypnotics, the drug with the lowest purchase cost should be used. In other words don't use the `Z' drugs first-line. Patients who have not responded to one of these drugs should not be prescribed another.
Contractility increased in a concentration-dependent fashion for both drugs. milrinone However, the effect for were.
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Fig. 4. Separation of ET 1 ; , 6-OH-ET 2 ; , 7-OH-ET 3 ; and 8-OH-ET 4 ; a ; in capillary HPLC, b ; in pCEC and c ; in CEC mode. Instrument: HP 3D ; capillary: fused-silica 100 mm I.D., 23 cm packed LiChrospher 100 RP-18, 5 mm buffer: 75 mM ammonium formate pH 2.5acetonitrile 40: 60, v v separation conditions: a ; separation by pressure 12 bar; b ; separation by pressure 12 bar1voltage 27 kV; c ; separation by voltage 27 kV inlet outlet vial 12 bar injection: by pressure 12 bar; detection: on-column at 254 nm 55impurity of 3; 65impurity of 2; 7 85impurities of 4.
ECPs are very safe for almost all women, according to the U.S. Food and Drug Administration. As with all medic ation, check with your doctor to see if there is any reason you should not use ECPs.
Spreadability, texture, "mouth feel, " and increased shelf life to naturally liquid vegetable oils, hydrogenated oils are toxic and responsible for an enormous number of health problems. In addition to being formed in the hydrogenation process, trans bonds are also formed when unsaturated oils are heated to temperatures above the boiling temperature of water. The more unsaturated the oil, the more heat applied, the more trans bonds will be formed. Frying creates the most trans bonds of all common cooking methods. This is the reason frying with mono- and polyunsaturated fats is particularly bad for health. Extensive research has shown that all vegetable oil with trans bonds, including all hydrogenated vegetable oils, have contributed to heart disease, cancer, diabetes and other diseases because of these bonds. Trans fatty acids are found in many processed foods - all deep fried foods, candy bars, cookies, cakes, pies, pastry, lunch meat, potato chips, French fries, etc. Both minimally processed saturated and monounsaturated fats are essential and good for health. Saturated fat is found in all meats as well as palm oil and coconut oil. Butter contains both saturated and unsaturated fats. Canola oil is definitely not healthy for the cardiovascular system. Like rapeseed oil, its predecessor, canola oil is associated with fibrotic lesions of the heart. It also causes vitamin E deficiency and undesirable changes in the blood platelets. Furthermore, it seems to retard growth, which is why the FDA does not allow the use of canola oil in infant formula. Saturated fats do not form trans bonds when heated. Therefore they are the safest fats to use in cooking. There is no evidence that saturated fats cause any health problems whatsover, contrary to much that has been written. On the contrary, a lack of fatty acids, including saturated fats, has been linked to many health problems. Saturated fats in meat and coconut do not have to be extracted. Other oils need to be extracted. Oil is extracted using one of two methods -- mechanical or chemical. Chemical extraction, often called solvent extraction, is the most common and cost efficient method. It employs high heat and a series of chemical processes, primarily exposure to hexane gas, to remove and refine the oil. Such an extraction process creates trans bonds and unhealthy oils. Mechanical extraction is also called cold pressed or expeller pressed. In this method oil is pressed from the source with hydraulic presses. Mechanical extraction creates healthy oils. Our recommended oils and fats not in order of preference ; are: 1 ; saturated fats from meat, coconut oil and palm oil 2 ; olive oil monounsaturated.
View and opinions expressed in the bulletin are those of the authors and not necessarily of the organization. Annual subscription Inland Rs. 15.00 Foreign: Sea Mail US$ 4 for all countries Air Mail: Asia US $ 6; Africa & Europe US $ 9; Canada & USA -- $ 11 Edited by Ravi Narayan, 326, 5th Main, 1st Block, Koramangala, Bangalore-560034 Printed by Thelma Narayan at Pauline Printing Press, 44, Ulsoor Road, Bangalore560042 Published by Thelma Narayan for Medico Friend Circle, 326, 5th Main, 1st Block, Koramangala, Bangalore-560034 and procardia.
1. Elizabeth L Tanzi, et al. Lasers in dermatology: Four decades of progress. JAAD 2003; 49 1 ; : 1-31 2. Jackson BA. Lasers in ethnic skin: A review. JAAD 2003; 48 6 ; : 13-138 3. Altshuler GB et al. Extended theory of selective photothermolysis. Lasers Surg Med. 2001; 29 5 ; : 416-32 4. Fitzpatrick RE et al. Collagen tightening induced by carbon dioxide laser versus erbium: Yag laser. Lasers Surg Med 2000; 27 5 ; : 395-403 5. Absten GT.Physics of light and lasers. Obstet Gynecol Clin North 1991; 18 3 ; : 407-27 6. Ratner D et al. Cutaneous laser resurfacing. JAAD September 1999; 41 3 ; : 365-92 7. Alam M et al. A prospective trial of fungal colonization after laser resurfacing of the face: correlation between culture positivity and symptoms of pruritis. Dermatol Surg 2003; 29 3 ; : 255-60 8. Cantatore J et al. Laser surgery : An approach to the pediatric patient. JAAD2004; 50 2 ; : 165-84 9. Dover J et al. Guideline of care for laser surgery. JAAD 1999; 41 3 ; : 484-95 10. Weisberg NK et al. Pigmentary changes after alexandrite laser hair removal. Dermatol Surg 2003; 29 4 ; : 415-9 11. Nayomi E et al. Treatment of reticular leg veins with a 1064nm long-pulsed Nd: YAG laser. JAAD 2003; 48 1 ; : 7681 12. Wendelin DS et al. Hypertrichosis. JAAD 2003; 48 2 ; : 16179 13. Ross EV et al. Treatment of pseudofilliculitis barbae in skin types IV, V, and VI with a long-pulsed neodymium: yttrium aluminum garnet laser. JAAD 2002; 47 2 ; : 263-70 14. Oslen EA. Methods of hair removal. JAAD 1999; 40 2 ; : 14358 15. Nanni CA et al. Laser-assisted hair removal: Side effects of Q-switched Nd: YAG, long-pulsed, and alexandrite lasers. JAAD 1999; 41 2 ; : 165-71 16. Hamilton MM. Laser treatment of pigmented and vascular lesions in the office. Facial Plast Surg 2004 Feb; 20 1 ; : 639 17. Kuperman-Beade M et al. Laser removal of tattoos. J Clin Dermatol 2001; 2 1 ; : 21-5 18. Prinz BM et al. Efficacy of laser treatment of tattoos using lasers emitting wavelengths of 532nm, 755nm and 1064nm. Dr J Dermatol 2004; 150 2 ; : 245-51.
YPF Oil Argentina ; Argentina Govt. Oil contaminants in water have caused severe medical problems among Mapuche children and zestril.
Potential side effects: Rash, headache and nausea. Severe rash can be life-threatening. Signs may include fever, blistering, oral lesions, conjunctivitis pink eye, which if untreated may result in permanent loss of vision ; , swelling, muscle or joint aches, or general malaise feeling unwell, as with a flu ; . Stop taking Rescriptor if these symptoms appear and seek immediate medical attention. Potential drug interactions: Do not use Zocor simvastatin ; or Mevacor lovastatin ; lipid lowering agents; suggested alternatives are Lipitor atorvastatin ; , Lescol fluvastatin ; , Baycol cerivastatin ; , and Peavachol pravastatin, the one that looks best on paper for people on protease inhibitors ; . Alternatives should still be used with caution because of potential for liver toxicity. Seldane terfenadine ; , Hismanal astemizole ; , Propulsid cisapride ; , Versed midazolam ; and Xanax alprazolam ; should not be used concurrently with Rescriptor. Potential toxicity when given with Biaxin clarithromycin ; , Dapsone USP, Mycobutin rifabutin ; , ergot derivatives such as Wigraine and Cafergot ; , Procardia nefedipine ; , Coumadin quinidine ; and warfarin. Tegretol carbamazepine ; , an anti-seizure medication used to treat peripheral neuropathy, phenobarbital, Dilantin phenytoin ; , Mycobutin rifabutin.
Comment: This diabetic woman was treated for pneumonia and parapneumonic effusion. Back pain and leg weakness after 5 days of hospitalization led to the diagnosis of S agalactiae osteomyelitis complicated by an epidural abscess. The initial source of infection and trandate.
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Families should be aware that the Temple Shir Tikvah Religious School curriculum involves a number of food-based activities, some of which may contain nuts. In addition, we sometimes go outdoors. If your child has serious allergies, it is important for you to let us know so we can help you and your child have a safe and enjoyable experience at Religious School. You should also fill out a health form which is included with the registration materials ; so that your child's teacher has the information s he needs to help your child be safe. We also request that you meet with your child's teacher early in the year to review your child's particular needs. If your child carries an epi-pen, it is very important that you meet with the teacher so that s he will be prepared to help your child should the need arise.
The acquisitions and the costs of upgrading our pharmaceutical manufacturing facilities. DIVIDEND In light of these results and in line with the Group's progressive dividend policy, the Board is recommending a final dividend of 2.75 pence 2001: 2.5p ; , an increase of 10%. This, together with the interim dividend of 1.37 pence paid in April 2002 gives a total for the year of 4.12 pence 2001: 3.75 pence ; . The total dividend is covered 2.4 times by profit after tax. If approved at the Annual General Meeting on 16 October 2002, the final dividend will be paid to shareholders on the Register as at 1 November 2002, on 27 November 2002. PEOPLE In November 2001, Ian Page was appointed Chief Executive following the resignation of Gary Evans. Prior to this he was Managing Director of NVS and played a major role in establishing this division's leading position within its marketplace. Martin Roach replaced Ian as Managing Director at NVS in January this year. He has extensive experience within the distribution and veterinary pharmaceuticals industries both in Europe and North America. In January we also announced, with great sadness, the sudden death of Peter Redfern who from 1997, as Chairman, guided the Group through the MBO to flotation. Although he is missed, he has left with us a strong legacy upon which we shall build further. On behalf of the Board and shareholders I would like to welcome all the staff who have and lasix.
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DISCUSSION The antibacterial effect of antibiotics is determined in part by the concentration in the immediate vicinity of the bacteria. The effective concentration in serum is the fraction of the drug that is free and not bound to protein 2, 7, 8 ; . The equilibrium between bound and free antibiotic acts as a reservoir when the free component diffuses into the tissues, so that the tissue concentration is mainly dependent on the blood-tissue gradient 2 ; . During bronchial inflammation, there may be leakage of proteinbound antibiotic into the sputum in addition to the diffusion of the free drug. As the inflammation subsides, leakage of the bound drug would become less important. May has pointed out three problems in assessing the significance of antibiotic concentrations in sputum 11 ; . First, the relationship of the concentration in sputum to the tissue level at the site of infection cannot be accurately assessed. However, in his experience the therapeutic value of an antibiotic can be more nearly correlated with the sputum concentration than with the serum concentration. Second, dilution of sputum with saliva may cause experimental errors in the estimation of antibiotic concentrations in sputum. Third, because of the presence of bacteria in the sputum, a diffusion method rather than titration must be used in determin and vasotec.
Sedation and analgesia" comprise a continuum of states ranging from minimal sedation anxiolysis ; through general anesthesia. Definitions of levels of sedationanalgesia, as developed and adopted by the ASA, are given in table 1. These Guidelines specifically apply to levels of sedation corresponding to moderate sedation frequently called conscious sedation ; and deep sedation, as defined in table 1.
Please rate each of the following overall strategies for treating prominent DEPRESSIVE SYMPTOMS in an elderly patient with dementia and agitation. In Survey Question 24, you will be able to specify your choice of antidepressants. ; Please note that the severity ranges refer to depression rather than agitation and lisinopril.
A better strategy for developing more effective cholesterol-lowering drugs may come from the first studies of the structural mechanism by which the widely prescribed statin drugs, such as Lipitor and Zocor, lower cholesterol. In an article published in the May 11, 2001, issue of the journal Science , Howard Hughes Medical Institute HHMI ; investigator Johann Deisenhofer at the University of Texas Southwestern Medical Center, and colleague Eva S. Istvan, reported x-ray crystallography data that show how six different statin compounds fit into the active site of the enzyme HMG-CoA reductase HMGR ; . HMGR catalyzes a key step in cholesterol production. After making crystals of the HMGR protein bound to each of the statins, Deisenhofer and Istvan then passed a beam of x-rays through the crystals. By analyzing the pattern of diffraction created as the X-rays bounced off atoms in the crystals, the scientists deduced the three-dimensional structures of the drugs bound to HMGR. Deisenhofer and Istvan found that statins bind to HMGR's active site -- the catalytic region of enzymes that binds biological substances -- and prevent the enzyme from producing a molecule that is crucial to cholesterol synthesis. The studies also showed that statins do not block an additional region of HMGR's active site, suggesting that the drugs might be improved. Statins that target HMGR more effectively might prove better at reducing the enzyme's activity. Deisenhofer and Istvan studied compactin also known as mevastatin ; , simvastatin Zocor ; , fluvastatin Lescol ; , cerivastatin Baycor ; , atorvastatin Lipitor ; , and rosuvastatin Crestor ; . Simvastatin and two others not studied -- lovastatin Mevacor ; and pravastatin Pragachol ; -- closely resemble compactin, which is not in clinical use. "Although there is room for improvement in these drugs, " said Deisenhofer, "there is no desperate need because the known inhibitors work quite well." Deisenhofer emphasized that he and his colleagues undertook these studies to learn more about how the cholesterol-synthesis pathway works at the molecular level. "It was clear that statins compete with one of the substrates for binding to the enzyme, " said Deisenhofer. "But it was not known whether.
As anti-VEGF substances were documented during clinical trials. Results: PDT monotherapy leads to a transient occlusion of the choriocapillary layer, which often recovers, but may be persistent in 50% of treated eyes following repeated treatments. An increased expression of vascular endothelial growth factor VEGF ; and VEGF receptors was seen by immunostaining in human eyes. Combination with IVTA reduced the number of retreatments necessary and led to a mean improvement in visual acuity of 1.2 lines, avoiding the vision loss often seen with PDT alone. Combination with antiVEGF agents led to improved outcome regarding vision and retreatment needs in phase I II trials. Several phase III trials combining PDT and adjunct drug therapy are ongoing. In the VISION trial Macugen offered improved results in lesions with predominantly classic CNV which had received prior or additional PDT. In the FOCUS study a combination of Lucentis with standard PDT led to a positive response in 94% of eyes, vision improvement was seen in 31% with combination therapy in nave lesions. Conclusion: Combination therapy with PDT and anti-VEGF compounds seems to offer an excellent strategy to potentially improve vision outcome and reduce re-treatment efforts. Results of phase III trials will allow to evaluate this option and vytorin.
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Of ALL due to the higher rates of ALL among Hispanic children. Therefore, the higher ALL rates in LA can be explained by the higher proportion of Hispanic children in LA, and the increase in ALL rates for LA can be at least partially explained by increases in the percentage of Hispanic children in LA. Ongoing monitoring of childhood leukemia trends, as well as epidemiologic and basic laboratory studies, are needed to develop a better understanding of the pathogenesis of childhood leukemia and an enhanced ability to explain changes in leukemia incidence over time. Figure I.6 illustrates the incidence of ALL for white and black children for the period from 1977 to 1995. While the incidence of ALL for white children increased at an overall rate of approximately 1% per year since 1977, there was no apparent increase in ALL rates for black children during this same period.
Performed meta-analysis using a fixed effects Peto ; model. Main results: A total of fifty two trials met inclusion criteria for one or more of the comparisons in the review. Sixteen studies compared a group programme with a self-help programme. There was an increase in cessation with the use of a group programme N 4, 395, odds ratio 1.97, 95% confidence interval 1.57 to 2.48 ; . Group programmes were more effective than no intervention controls six trials, N 775, odds ratio 2.19, 95% confidence interval 1.42 to 3.37 ; . There was no evidence that group therapy was more effective than a similar intensity of individual counselling. There was limited evidence that the addition of group therapy to other forms of treatment, such as advice from a health professional or nicotine replacement produced extra benefit. There was variation in the extent to which those offered group therapy accepted the treatment. There was limited evidence that programmes which included components for increasing cognitive and behavioural skills and avoiding relapse were more effective than same length or shorter programmes without these components. This analysis was sensitive to the way in which one study with multiple conditions was included. There was no evidence that manipulating the social interactions between participants in a group programme had an effect on outcome. Reviewers' conclusions: Groups are better than self-help, and other less intensive interventions. There is not enough evidence on their effectiveness, or cost-effectiveness, compared to intensive individual counselling. The inclusion of skills training to help smokers avoid relapse appears to be useful although the evidence is limited. There is not enough evidence to support the use of particular components in a programme beyond the support and skills training normally included and zebeta.
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Summaries of the papers quoted appear in Annex IV. Healthy volunteers.
He noted that they back up a study completed last year, funded by pfizer, showing that lipitor is better than pravachol in limiting the progression of disease in coronary arteries and norvasc.
In practice, the P.B.M.s will be required to carry a choice of drugs in every therapeutic category. But how do you define a therapeutic category? Are drugs like Nexium and Prilosec and Prevacid--all technically known as proton-pump inhibitors--in one category, and the H2 antagonists in another? Or are they all in one big category? The first approach maximizes the choices available. The second approach maximizes the bargaining power of P.B.M.s. Deciding which option to take will have a big impact on how much we end up paying for prescription drugs--and it's a decision that has nothing to do with the drug companies. It's up to us; it requires physicians, insurers, patients, and government officials to reach some kind of consensus about what we want from our medical system, and how much we are willing to pay for it. AstraZeneca was able to do some chemical sleight of hand, spend half a billion on advertising, and get away with the "reinvention" of its heartburn drug only because that consensus hasn't yet been reached. For sellers to behave responsibly, buyers must first behave intelligently. And if we want to create a system where millions of working and elderly Americans don't have to struggle to pay for prescription drugs that's also up to us. We could find it in our hearts to provide all Americans with adequate health insurance. It is only by the most spectacular feat of cynicism that our political system's moral negligence has become the fault of the pharmaceutical industry. There is a second book out this fall on the prescription-drug crisis, called "Overdosed America" HarperCollins; .95 ; , by John Abramson, who teaches at Harvard Medical School. At one point, Abramson discusses a study that he found in a medical journal concluding that the statin Pravzchol lowered the risk of stroke in patients with coronary heart disease by nineteen per cent. That sounds like a significant finding, but, as Abramson shows, it isn't. In the six years of the study, 4.5 per cent of those taking a placebo had a stroke versus 3.7 per cent of those on Pravachol. In the real world, that means that for every thousand people you put on Pravacuol you prevent one stroke--which, given how much the drug costs, comes to at least .2 million per stroke prevented. On top of that, the study's participants had an average age of sixty-two and most of them were men. Stroke victims, however, are more likely to be female, and, on average, much older--and the patients older than seventy in the study who were taking Prabachol had more strokes than those who were on a placebo. Here is a classic case of the kind of thing that bedevils the American health system--dubious findings that, without careful evaluation, have the potential to drive up costs. But whose fault is it? It's hard to blame Pravachol's manufacturer, Bristol-Myers Squibb. The study's principal objective was to look at Pravachol's effectiveness in fighting heart attacks; the company was simply using that patient population to make a secondary observation about strokes. In any case, Bristol-Myers didn't write up the results. A group of cardiologists from New Zealand and Australia did, and they hardly tried to hide Pravachol's shortcomings in women and older people. All those data are presented in a large chart on the study's third page. What's wrong is the context in which the study's findings are presented. The abstract at the beginning ought to have been rewritten. The conclusion needs a much clearer explanation of how the findings add to our understanding of stroke prevention. There is no accompanying commentary that points out the extreme cost-ineffectiveness of Pravachol as a stroke medication--and all those are faults of the medical journal's editorial staff. In the end, the fight to keep drug spending under control is principally a matter of information, of proper communication among everyone who prescribes and pays for and ultimately uses drugs about what works and what doesn't, and what makes economic sense and what doesn't--and medical journals play a critical role in this process. As Abramson writes.
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While it was not clear from the medical record when Dr. Deep initiated therapy with Pravachol 20 mg, it appears to have been prescribed in late November, 1997.
Minshew NJ, Goldstein G, Muenz LR, Payton JB. 1992. Neuropsychological functioning in nonmentally retarded autistic individuals. J Clin Exp Neuropsychol. 14: 749--761. Minshew NJ, Goldstein G, Siegel DJ. 1997. Neuropsychologic functioning in autism: profile of a complex information processing disorder. J Int Neuropsychol Soc. 3: 303--316. Minshew NJ, Luna B, Sweeney JA. 1999. Oculomotor evidence for neocortical systems but not cerebellar dysfunction in autism. Neurology. 52: 917--922. Minshew NJ, Sung K, Jones BL, Furman JM. 2004. Underdevelopment of the postural control system in autism. Neurology. 63: 2056--2061. Mottron L, Burack JA. 2001. Enhanced perceptual functioning in the development of autism. In: Burack JA, Charman N, Yirmiya N, Zelazo PR, editors. The development of autism: perspectives from theory and research. Mahwah, NJ: Erlbaum. p. 131--148. Mottron L, Dawson M, Soulieres I, Hubert B, Burack JA. 2006. Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. J Autism Dev Disord. 36: 27--43 Mundy P, Neal R. 2001. Neural plasticity, joint attention, and a transactional social orienting model of autism. Int Rev Ment Retard. 23: 139--168. Narumoto J, Okada T, Sadato N, Fukui K, Yonekura Y. 2001. Attention to emotion modulates fMRI activity in human right superior temporal sulcus. Cogn Brain Res. 12: 225--231. Ojemann J, Ojemann G, Lettich E. 1992. Neuronal activity related to faces and matching in human right nondominant temporal cortex. Brain. 115: 1--13 Ozonoff S, Strayer DL. 2001. Further evidence of intact working memory in autism. J Autism Dev Disord. 31: 257--263. Pelphrey K, Adolphs R, Morris JP. 2004. Neuroanatomical substrates of social cognition dysfunction in autism. Ment Retard Dev Disabil Res Rev. 10: 259--271. Pelphrey KA, Mitchell TV, McKeown M, Goldstein J, Allison T, McCarthy G. 2003. Brain activity evoked by perception of human walking: controlling for meaningful coherent motion. J Neurosci. 23: 6819--6825. Pennington BF, Ozonoff S. 1996. Executive functions and developmental psychopathology. J Child Psychol Psychiatry. 37: 51--87. Peterson BS, Skudlarski P, Gatenby JC, Zhang H, Anderson AW, Gore JC. 1999. An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Soc Biol Psychiatry. 45: 1237--1258. Pierce K, Muller R-A, Ambrose J, Allen G, Courchesne E. 2001. Face processing occurs outside the fusiform `face area' in autism: evidence from functional MRI. Brain. 124: 2059--2073. Piggot J, Kwon H, Mobbs D, Blasey C, Lotspeich L, Menon V, Bookheimer S, Reiss AL. 2004. Emotional attribution in high-functioning individuals with autistic spectrum disorder: a functional imaging study. J Acad Child Adolesc Psychiatry. 43: 473--480.
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When to Take Statins Lipitor, Zocor, Pravachol, Lescol, Crestor, Lovastatin ; The liver produces cholesterol at night when dietary intake is the lowest. For this reason, Zocor, Mevacor, Lescol were studied for administration at bedtime to assure maximum effectiveness. While it is true that Lescol, Mevacor, and Zocor are slightly more effective for lowering cholesterol when they're taken in the evening instead of the morning, the other three statins Lipitor, Crestor, and Pravachol ; can be taken without regard to the time of day. Statins act by inhibiting the enzyme HMG-CoA reductase, which controls synthesis of cholesterol in the liver. New data suggest that statins may do more than just lower cholesterol. Studies have shown that statins also may reduce artery inflammation, reduce the ability of platelets to clump, and reduce the proliferation of smooth muscle cells in the arteries, each of which can further reduce patients' chances of experiencing cardiovascular events. Therefore, it is not surprising that statins are some of the most prescribed medications in the United States. Approximately 12 million Americans currently take statins; however, data suggest that another 20 million Americans could benefit from taking statins. Atorvastatin Lipitor ; is Omnicare's selected statin.
Table 1. Major Brand of Statin Drugs Brand Advicor Altocor Caduet Crestor Lescol XL Lipitor Lovastatin Mevacor Pravachol Zocor.
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Significant obstacles. ERISA sharply limits a state's ability to raise revenue to fund these health programs. Several states have responded to these limitations by seeking waivers. Despite these obstacles, 8 states already have enacted comprehensive health reform measures, and virtually every state is considering legislative reform. PMID: 7978662 [PubMed - indexed for MEDLINE].
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